🟢 What it is

Salmon DNA Injection in Korea—sometimes called PN (Polynucleotide) therapy—is a regenerative skin treatment that uses DNA fragments extracted from salmon sperm. These polynucleotides are highly biocompatible with human skin, which means they integrate safely and effectively into the dermis to repair, regenerate, and rejuvenate skin at a cellular level.

Unlike fillers that simply add volume, salmon DNA injections work by stimulating fibroblasts, which boosts:

• Collagen and elastin production.
• Cell regeneration and healing.
• Skin barrier strengthening.
• Improved hydration and elasticity.

In Korea, salmon DNA injections are considered a foundational regenerative treatment and are widely used in skin booster programs (such as Rejuran Healer).

🟢 Why it’s Done

Patients in Korea choose salmon DNA injections for natural and long-term skin improvement:

➡️ Anti-aging: Reduces fine lines and strengthens thinning skin.
➡️ Repair: Heals damaged skin caused by UV exposure, pollution, or acne.
➡️ Texture improvement: Smooths roughness and restores evenness.
➡️ Brightening effect: Improves dull skin and reduces inflammation-driven pigmentation.
➡️ Barrier protection: Strengthens sensitive or compromised skin.
➡️ Post-procedure healing: Speeds recovery after lasers, microneedling, or chemical peels.

This aligns with the K-beauty philosophy of prevention and natural rejuvenation rather than drastic changes.

🟢 Alternatives

Salmon DNA therapy is unique, but alternatives in Korea include:

🔹 Rejuran Healer (PN): A branded, refined form of salmon DNA injection widely used in Korean clinics.
🔹 Profhilo: Hyaluronic Acid-based bioremodeling for hydration and elasticity.
🔹 Exosome boosters: Cellular messengers for repair and anti-inflammatory effects.
🔹 PRP (Platelet-Rich Plasma): Uses the patient’s plasma to repair and heal skin.
🔹 HA skin boosters (Skinvive, Restylane Vital): Primarily for hydration, not repair.

Many clinics in Korea combine salmon DNA with HA or exosomes for multi-layered results.

🟢 Preparation

Preparation helps ensure best results:

➡️ Consultation: Doctor examines skin condition (aging, scars, sensitivity).
➡️ Medical history: Patients disclose allergies, autoimmune conditions, or recent treatments.
➡️ Avoid blood thinners: No aspirin, ibuprofen, fish oil, or alcohol for 3–5 days.
➡️ Skin care prep: Avoid retinoids, chemical peels, or exfoliants before treatment.
➡️ Expectation setting: Results are gradual and cumulative, best after several sessions.

🟢 How it’s Done

The procedure usually takes 20–30 minutes:

1. Cleansing & sterilization of the treatment area.
2. Numbing: Topical anesthetic cream is applied.
3. Microinjections:
   • Salmon DNA solution is injected into the dermis in a grid-like pattern.
   • Ultra-fine needles or injector devices are used.
   • Common treatment areas: face, under-eyes, neck, décolletage, and hands.
4. Soothing care: Cooling masks or LED light therapy applied post-treatment.

Korean dermatologists often recommend 3–4 sessions, spaced 3–4 weeks apart.

🟢 Recovery

Recovery is minimal compared to lasers or peels:

🔹 Downtime: Very little—patients resume normal activities quickly.
🔹 Redness & bumps: Small injection marks that settle within 24–48 hours.
🔹 Mild swelling: Temporary, usually gone in 1–2 days.
🔹 Results:

• Early glow within 2–3 weeks.
• Stronger repair and elasticity after several sessions.
• Long-term improvements in skin tone and texture.

✅ Post-care in Korea includes:

• Avoid saunas, alcohol, and heavy workouts for 24–48 hours.
• Daily sunscreen to protect rejuvenated skin.
• Hydrating, gentle skincare to support repair.

🟢 Complications

Salmon DNA injections are very safe, but mild side effects may occur:

⚠️ Mild issues:

• Redness, tenderness, or small bumps.
• Temporary bruising at injection sites.

⚠️ Rare risks:

• Infection (if aftercare is neglected).
• Uneven distribution (usually corrects as skin heals).
• Allergic reaction (extremely rare due to high biocompatibility).

➡️ Korean dermatologists minimize risks with ultra-fine needles, sterile injector protocols, and combination therapies.

🟢 Treatment Options in Korea

Korean clinics use salmon DNA injectables in many ways:

🔹 Rejuran Healer (PN): The most popular branded version of salmon DNA injections.
🔹 Rejuran i: For delicate under-eye rejuvenation.
🔹 Rejuran S: For acne scar repair.
🔹 Standalone salmon DNA cocktails: Used in mesotherapy-style boosters.
🔹 Combination therapy: Salmon DNA + HA boosters for hydration, or salmon DNA + exosomes for advanced regeneration.

🟢 Final Thoughts

Salmon DNA Injections in Korea are one of the most trusted skin regeneration therapies, focusing on healing, repair, and natural anti-aging.

➡️ Best for patients with fine lines, acne scars, dull skin, or weakened skin barrier.
➡️ Results are gradual, subtle, and long-lasting, making them ideal for patients who prefer natural improvements.
➡️ With Korea’s advanced protocols and layering techniques, salmon DNA therapy is often combined with other boosters for maximum results.

In summary: Salmon DNA injections in Korea are a safe, effective, and regenerative treatment, helping the skin heal, strengthen, and glow—perfectly in line with the Korean beauty ideal of healthy, radiant skin.