Overview
Systemic inflammatory dermatosis refers to a group of skin disorders characterized by widespread inflammation that affects not only the skin but may also involve internal organs and systems. These conditions are often autoimmune in nature and can cause chronic skin symptoms along with systemic complications. Early diagnosis and treatment are essential to control disease progression and improve quality of life.
What is Systemic Inflammatory Dermatosis?
Systemic inflammatory dermatosis includes diseases where immune system dysfunction causes inflammation in the skin and other body parts. Examples include lupus erythematosus, dermatomyositis, and systemic sclerosis. These diseases manifest with skin rashes, ulcers, and other dermatological changes while potentially affecting joints, muscles, lungs, kidneys, and other organs.
Symptoms
- Widespread red or purple rashes, often with scaling
- Skin thickening or tightening
- Painful or itchy skin lesions
- Ulcers or sores on the skin
- Fatigue and muscle weakness
- Joint pain or swelling
- Fever or other systemic symptoms
Causes
- Autoimmune dysfunction leading to chronic inflammation
- Genetic predisposition
- Environmental triggers such as infections, drugs, or UV exposure
- Dysregulated immune response attacking skin and organs
Risk Factors
- Family history of autoimmune diseases
- Female gender (more common in women)
- Exposure to certain medications or toxins
- Viral or bacterial infections triggering immune response
Complications
- Permanent skin damage or scarring
- Organ involvement leading to lung fibrosis, kidney failure, or heart disease
- Increased risk of infections due to immunosuppressive therapy
- Reduced quality of life due to chronic symptoms
Prevention
- Avoid known triggers like excessive sun exposure
- Early diagnosis and treatment to control inflammation
- Regular monitoring for systemic involvement
- Healthy lifestyle with balanced diet and stress management
Treatment Options in Korea
Korea offers advanced multidisciplinary care for systemic inflammatory dermatoses with dermatologists, rheumatologists, and immunologists collaborating closely:
- Medications
- Corticosteroids to reduce inflammation
- Immunosuppressants (e.g., methotrexate, azathioprine)
- Biologic therapies targeting specific immune pathways
- Topical treatments for skin lesions
- Monitoring and Support
- Regular blood tests and imaging to assess organ involvement
- Physical therapy for muscle weakness
- Patient education and psychological support
- Specialized Clinics
- Major hospitals like Seoul National University Hospital and Samsung Medical Center have dedicated clinics for autoimmune and inflammatory skin diseases
- Research and Clinical Trials
- Access to cutting-edge treatments through participation in clinical studies
